Evo-Devo - A Capella Science.mp3

[00:00.000] 作曲 : Timothy Blais
[00:08.396]Huxley
[00:10.196]B•Mac oh
[00:12.750]Carrol Carrol
[00:15.594]Could Stephen Jay yeah
[00:17.893]Davidson (and) Peter Go!
[00:19.961]See One cell divide and decide on a thousand fates
[00:25.115]Did you ever figure how they know？（B.Mac）
[00:30.759]We are built of modules combine in a planned out way
[00:36.176]Each new piece must be told where to go Oh
[00:41.328]Now there's a science helping us to understand
[00:44.910]How our cells encode this architectural plan
[00:47.488]Signalling each other with genetic tools Oh oh yeah
[00:52.097]Wow Phenotype the interface for mouse and man
[00:55.475]Genotype the files and the subprograms
[00:58.311]What then are the switch, circuit boards and boot code
[01:03.440]Evo-devo Looking at the logic in the ways that we grow
[01:06.815]Every gene directed by a signal key code
[01:09.650]Proteins that can activate, enhance or veto
[01:14.284]Evo-devo Signals are controlled by other genes that signal
[01:17.638]Calculating in a network Labyrinthal
[01:20.461]Where the heart and liver and the hands and feet go (Signal*5)
[01:25.104]Signal mapping tells each other what it ought to be yo
[01:28.982]With circuits so deeply built upon They're older than the paleo
[01:33.858]The Paleozoic era baby
[01:35.925]In a crucial pathway changes tend to get torpedoed
[01:39.755]Where they go calamity goes As this cyclopic sheep knows
[01:45.687]See down they cascade like a domino
[01:47.232]Like you and I drosophila
[01:48.799]The path that makes us optical
[01:50.088]Was laid a long long time ago
[01:51.378]Back before we blew up the Cambrian like a bomb bomb
[01:53.967]Now my eye protein can make you see out of your bom bom
[01:56.795]And hedgehog and its relatives like Indian and Sonic
[01:59.375]Set up set up in a gradient on segments embryonic
[02:02.197]Spilt fore brains and asymmetric parts depend upon it
[02:04.788]Flipping on genetic switches and logic
[02:07.609]From devo to evo adult and embryo
[02:10.195]Mostly don't evolve in the genes of the genome
[02:13.019]Safer the mutation aimed at regulation
[02:15.595]Keep the building blocks and swap their activation
[02:18.423]From devo to evo parts have alter egos
[02:20.994]Homologs evolved from repeats in the schema
[02:23.833]Switch a couple bases in the proper places
[02:26.408]You'll be watching flies grow legs out of their faces Oh yeah
[02:31.048]Evo-devo stick around for Modern Synthesis the sequel
[02:34.381]Only by combining can a new theory grow
[02:37.203]Evolution and development amigos
[02:41.828]Evo-devo signals trigger patterns of complexity so
[02:45.189]Switching up the switch of a signalling node
[02:48.011]Gives a modular and simple way to evolve (switch*5)
[02:52.644]Look at how our spinal segments generate a neat row
[02:56.764]Built on molecular clock one cycle one vertebra
[03:01.394]One vertebra one vertebra baby
[03:03.451]Speeding up its rate is snake's developmental cheat code
[03:07.818]That and where a lizard's feet grow
[03:10.658]They turn off distal aminos
[03:14.249]Evo-devo this is how we go from single cells to people
[03:17.584]Every generation and in life primeval
[03:20.159]Life in variations endless and beautiful Bababoom
[03:25.069]From devo to evo larva to mosquito
[03:27.159]Patterns are resolved as the signals proceed yo
[03:29.483]Map out a gene with a glow tag
[03:32.037]Kill it with a morpholino
[03:33.858]Short oligo morpholino baby
[03:35.923]From devo to evo voyage of the Beagle
[03:37.991]Body plans evolve when protein steer the genome
[03:40.326]In this manner life's beauty grows aesthetica in vivo
[03:45.712]Evo-devo